While working on a writing project on the island of Ischia, a married woman (Bosworth) enters into an affair with a younger man.

On the day after his fortieth birthday, the family man and computer analyst George Grieves goes to the Mt. Abaddon Hospital for a routine procedure of colonoscopy with Dr. Sharazi. Along his birthday party, his friends and family tell many cases of medical errors, and George is worried about. After the surgery, George finds that his surgery had complications because of a homonymous patient, and he had received a thoracoscopic sympathectomy instead. While interned, George discloses bizarre and dark secrets about the East Wing of the hospital while his wife and family have to take a decision about his fate.